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In emergencies, such as hyperglycemic coma, it can be given intravenously (mostly by infusion because i. v. injections have too brief an action; plasma t1/2 ~ 9 min). With the usual subcutaneous application, the effect is evident within 15 to 20 min, reaches a peak after approx. 3 h, and lasts for approx. 6 h. Lispro insulin has a faster onset and slightly shorter duration of action.
Scopolamine penetrates the blood-brain barrier faster than does atropine (pKa = 9), because at physiologic pH a larger proportion is present in the neutral, membrane- permeant form. In psychotic excitement (agitation), sedation can be achieved with scopolamine. Unlike atropine, scopolamine exerts a calming and amnesiogenic action that can be used to advantage in anesthetic premedication.

 

Oral anticoagulants. Structurally related to vitamin K, 4-hydroxycoumarins act as “false” vitamin K and prevent regeneration of reduced (active) vitamin K from vitamin K epoxide, hence the synthesis of vitamin K-dependent clotting factors. Coumarins are well absorbed after oral administration. Their duration of action varies considerably.
The cause of death is nervous system damage and seizures. In humans DDT causes acute neurotoxicity only after absorption of very large amounts. DDT is chemically stable and degraded in the environment and body at extremely slow rates. As a highly lipophilic substance, it accumulates in fat tissues.Widespread use of DDT in pest control has led to its accumulation in food chains to alarming levels.

 

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